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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

人命关天,安全至上。
豆瓣网友“Banchengyansha”称:“电视剧版的场景很精致,也很贴合原著。”

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

In early December, authorities announced that market circuit breakers would be introduced become effective from January 1 in an effort to limit the volatility seen during the savage, summer sell-off from June. The circuit breakers would see trading in shares, options and futures halted for 15 minutes if they fell by more than 5 per cent. On their first day of use, that first threshold was breached just after the return from the lunchbreak, prompting a 15-minute halt.
28 June

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

源于:muscle(n 肌肉)

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

2.纳米比亚

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

这支队伍需要更多的天赋,他们需要大修。对魔术而言,最能吸引天赋到来的方式一直以来都是选秀。
Those concerns are casting a heavy shadow over a two-day meeting of G20 central bank governors and finance ministers due to start tomorrow. The International Monetary Fund this week already warned that it was poised to downgrade its forecast for global growth this year, saying the leading economies needed to do more to boost growth.
骑行背带是专为小宝宝设计的,以减轻家长的负担。
上周四公布的一项数据显示,两所中国顶尖大学跻身今年《泰晤士报高等教育专刊世界大学声誉排行榜》的前20名。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

[stik]
立场:为LGBT(指同性恋、双性恋和变性人)群体争取工作权益
Average years of work experience: 12 years
3. 经济已经在崩溃,2014年到2016年的GDP将会更加难看

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 广州:公租房可“柔性退出”
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

After an investigation, Rongchang police arrested Zhou on April 29 for endangering public security, according to the Chongqing Morning Post.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
From the themed collection: 政策利好频仍 长租公寓市场活跃
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Exports to both South Korea and Asean countries fell by about 3 per cent, however, while those to re-exporter Hong Kong dropped by more than 16 per cent.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

201007/109869.shtml
associate

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 涂装公司能否进入开发商战略集采
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Sinta Nuriyah
tracks

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Best Companies rank: 68
这是连续第二个周末,委内瑞拉的社会主义政府开放与哥伦比亚长期封闭的边界,星期日上午6点,潜在的顾客们排成长蛇阵,穿过圣安东尼奥德尔塔奇拉整个小镇。有些人租了车,从10小时车程外的城市赶来。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

其中有铁环的那一个是在江苏西部的仪征市发现的。
顾伦德.查达哈的这部殖民题材电影讲的是1947年的英印权力移交及其余波。当时蒙巴顿勋爵夫妇的府邸有500名仆人,他们中有印度教徒、穆斯林和锡克教徒。休.博内威利和吉莉安.安德森饰演主人公夫妇。
While the political system will be fixated on preserving stability as new leaders take the helm, reduced economic flexibility could thwart Beijing's intentions to do so.
4.You Don't Like Most of Your Coworkers

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 东莞家具业老板跑路成风
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

爱德华卢斯(Edward Luce)

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

在周某投毒之后,他的一名唐姓同学发现了饮水机的水呈乳白色,还有一股刺鼻的气味。
6. 《出租车》(Taxi),导演贾法·帕纳西(Jafar Panahi)。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

新年英文祝福语大全Best wishes for the year to come! 恭贺新禧! Good luck in the year ahead! 祝吉星高照! May you come into a good fortune! 恭喜发财! Live long

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

我是否在维持健康的人际关系?在你的生活中,是否有一段关系需要你额外的关注?你是否需要给某人平反?在如何对待他人这个问题上,努力保持清醒的头脑。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Guangzhou and Shenzhen, benefiting from balanced development, took first and second place respectively in the rankings. Hangzhou ranked third, owing to its technological advantages. Wuhan, which had achieved a good balance between development and costs, was in fourth place, followed by Nanjing with its quality culture and lifestyle.
So many are tuning out. Denial. Truth is, bubbles are everywhere. Ready to blow. The evidence is accelerating, with only one obvious conclusion: Max 98% risk at a flashpoint. This 2014 crash is virtually guaranteed. There's but a narrow 2% chance of dodging this bullet.
《请以你的名字呼唤我》
优化区域发展格局。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

We should stipulate at this point that neither of us have any idea how good this draft is going to be because the college season is barely underway. It sure looks nice, what with all those freshmen stacked up together in the lottery.
推进生态保护和建设。
Welcome, and before we begin – please accept our apologies. Your four-hour nightmare wait at passport control should not be taken as a symptom of Britain's contempt for foreigners. It is merely a symptom of a woeful lack of spending on a key aspect of travel infrastructure in the run-up to a hugely important event. In other words, it's the government that hates you. Don't worry, they hate us too.
这份榜单的四所英国大学分别是剑桥大学、牛津大学和伦敦大学和帝国理工学院。东京大学也位列前20名。
adj. 剧烈的,严重的,严峻的,严厉的,严格的

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 并购终止 佛山照明剧烈波动
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

We will strive to boost employment and business startups.
单词capacity 联想记忆:

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

他说,“油价将波动上行。”

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 防止用于减税资金变成“唐僧肉”
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

As fall arrived and school began, D'Aloisio felt immense pressure to deliver for his backers. He needed to whip his algorithm into better shape, so he contracted a team of Israeli coders who specialize in natural language processing. Searching on Google, he found and hired a retired professor living in Thailand who'd written seminal books on the topic. 'He became our main scientist,' says D'Aloisio. 'He now works at Yahoo! in the Sunnyvale office.'

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

o Outside events can intrude.Consumer Reports, which raved about the Model S, reported a few “quirks” recently that included door handles that failed to activate and a center touch screen that went blank, blocking access to most of the car’s functions. Edmunds.com has had trouble with its Model S too. More reports like that will dent Tesla’s heretofore shining reputation.
人事工作类
China and its southern neighbour failed to come to an agreement on cross-border trade last month during Vietnamese president Truong Tan Sang's state visit to China, where he met with his counterpart Xi Jiping.
"This year's prize concerns a central economic problem: how to match different agents as well as possible," the academy said.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

这名43岁的女子被判处为期12个月的行为考察,并且不得再次拥有宠物。
Last year, the General Administration of Quality Supervision, Inspection and Quarantine conducted random quality inspections on 1,013 batches of such products, including consumer goods such as toys, paper diapers, clothing and kitchenware, with 415 found to be substandard, accounting for 40.9 percent of all sampled products, according to Han Yunping, spokesman for the administration.
Despite the huge production, the focus was on the 40 gorgeous models who walked the runway.
答:和青木桑一起处理分镜真的是一件很快乐的事呢。有一种“队伍里会有青木桑是毫无疑问的吧“这样的感觉。有了他,相信动画的表现就不会有问题了呢。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

neglect
embrace

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

最佳综艺小品:帕顿?奥斯瓦特(Patton Oswalt),《帕顿?奥斯瓦特:为掌声而鸣》(Patton Oswalt: Talking for Clapping)
约60%的学员尚未参加工作,另有30%的学员拥有不到两年的工作经验。
推动社会治理创新。
7.无人机
It seems that Christmas time is here once again, and it is time again to bring in the New Year. We wish the merriest of Christmas to you and your loved ones, and we wish you happiness and prosperity in the year ahead.又该迎接新的一年了。我们向你及你的亲人们致以最美好的祝福,愿你在新的一年里事业兴旺,幸福美满!

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

[?'?u?d]
Stanford's Zhenan Baohas has developed a super-flexible, super-durable, and super-sensitive material that can be the basis for future synthetic skin. People have tried developing synthetic skin before, but Baohas's material handles touch sensitivity better than any predecessor. It contains organic transistors and a layer of elastic, letting it stretch without taking damage. And it's self-powered—this skin contains a series of elastic solar cells.
他说,杂志和作者在这起最近发生的丑闻中都有不可推卸的责任,声明中还说,《肿瘤生物学》在2015年就已经因同行评议过程存在类似问题而撤销一些论文。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

我是否在担忧未来?担忧某些并未发生的事情会导致压力和焦虑。专注于当下,了解到这就是目前所存在的一切。
"Wholesale food prices suggest that pork, vegetable and fruit price inflation all eased last month," said Capital Economics before the figures came out. "

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

PRICE PER SQUARE FOOT: $667
其中一项被提议的改变是:要求租金管制型房屋的租户提供收入证明。
节目11 歌曲《我心永恒》,席琳-迪翁

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

尤吉利时机恰当和思虑周密的举动应该能扭转猛龙下滑的颓势。
celebrity
10. China watchers inthe United States will continue to postulate China’s declining growth rate inthe face of evidence that it is stable at over 7%. China will grow fasterin 2014 than in 2013.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 朝阳政务服务中心延时两小时
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 规范民宿应多一些“网约”思维
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Second, McDermott, a career 39.9% three-point shooter, addresses Oklahoma City's biggest roster weakness—a lack of perimeter options around Russell Westbrook—and remains on a bargain rookie deal through the end of next season.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Slice stems at a 45 degree angle.This leaves a larger exposed area so blossoms can absorb as much water as possible, and also allows stems to stand on point, s
Total Program Cost: $181,500 in either Philadelphia or San Francisco

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

圣加伦大学校友的薪资排名第三,为114449美元(按购买力平价调整后),排在艾哈迈达巴德的印度管理学院(Indian Institute of Management)和印度管理学院班加罗尔分校(IIM Bangalore)之后,这两所商学院校友的平均薪资分别为116476美元和116094美元。圣加伦大学还在职业服务质量方面排名第一。
根据花旗居屋(Citi Habitats)提供的数据,在布鲁克林拟于明年投放市场的6527套新出租屋中,有1442套分布在贝德福德-斯图文森(Bedford-Stuyvesant)、布什维克(Bushwick)和克林顿山(Clinton Hill)。就在不久前,这些社区都还被视为不热门的地区。
年末城镇登记失业率4.02%,为多年来最低;
China's consumer price index (CPI), a main gauge of inflation, rose by 1.6% in 2017, lower than the yearly control target of 3%, the National Bureau of Statistics (NBS) said on its website.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

纽约现在排名第7,比去年上升了15个名次。近年来,纽约的生活成本涨幅巨大,较2011年上升了42个名次。
The gig economy

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

而相对来说,普遍推出的新限购政策,并未让其他许多最近几个月表现突出的城市受到影响,房价同比依然大幅上涨。
archery;shooting;triathlon;Modern Pentathlon.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

圣保罗报的民意调查是基于在贝洛奥里藏特(Belo Horizonte)的米内朗球场( Mineirao)对693名球迷进行的采访,统计误差为4%左右。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

After rising every year since 2008 global gold supply plateaued last year, according to the World Gold Council. In China, the world’s biggest producer, it fell by a record 9 per cent, the second time output has fallen in the country since 1980.
charter
美国当地时间3月23日,由尼克森电视台举办的第26届儿童选择奖颁奖礼在加州洛杉矶的南加大体育中心举行。好莱坞女星克里斯汀·斯图尔特身着蓝色连体裤出席,大秀美腿。在颁奖典礼上斯图尔特先是凭借着《暮色》系列终结篇《破晓(下)》摘得了最受欢迎电影女演员奖。之后又再次凭借电影《白雪公主与猎人》夺得了最受欢迎女动作影星的宝座,成为了本次颁奖礼上唯一一个独揽双奖的明星。当颁奖嘉宾宣布斯图尔特获奖时,她从座位上站起前往领奖台,一路上被孩子们“围攻”以致差点摔倒。由此可见孩子们对这位女星的喜爱程度了。
除了作品被展示在谷歌主页,张天羽还获得了3万美元的大学奖学金。她所在的学校也将获得5万美元的谷歌教育科技拨款。谷歌还以她的名义向慈善机构捐赠了2万美元,用于给孟加拉的学校提供净水。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

中国(大陆及香港)在排行榜上新添了25个成员,增长数量超过其他任何国家,共计207家。三个国家今年首次在排行榜上亮相了:毛里求斯、斯洛伐克以及多哥。
In a separate report in early September, the World Meteorological Organization said the level of carbon dioxide in the air in 2013 was 42 percent above the level that prevailed before the Industrial Revolution. Other important greenhouse gases have gone up as well, with methane increasing 153 percent from the preindustrial level and nitrous oxide by 21 percent.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The fastest-rising sector is apparel, driven by Nike in sportswear as people pay more attention to health and fitness, and Zara, whose fast fashion is becoming increasingly popular in China.
Bigcommerce does particularly well among small retailers generating $1 million to $2 million in annual revenue, although its following with those in the $20 million to $30 million range is growing quickly. Roughly 70% of its existing customer base also runs a bricks-and-mortar store. For the past year, the developer has worked hard on responsive storefront templates that work equally well on mobile platforms and desktops—design is the number-one consideration for small e-commerce merchants, it says—and on relationships with partners of “adjacent” cloud services from the accounting, payments, customer relationship management, and payroll management worlds.
9、《神奇动物在哪里》

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

报告发现,艺术学、农学、工学专业的学生创业意愿最高,而历史学和理科专业的学生创业兴趣相对较低。
undeniable
Season\'s greetings and sincere wishes for a bright and happy New Year!

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 日卫浴企业看好中国市场
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

榜单的前20名中,除了排名第四的复旦大学和第六名的北京大学这两所综合类高校之外,其余席位多被财经类和理工类高校占据。
[i'li:g?l]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

这些弊端是很现实的,但是也有很多方法来回避它们。比如说,你可以利用你的谋生工作向雇主展示你努力工作的诚意。并且你也可以在工作之余继续找其他的好工作。
These were no lightweight pundits. The eminent historian Margaret MacMillan, in an essay for Brookings in December 2013, said, “We are witnessing, as much as the world of 1914, shifts in the international power structure, with emerging powers challenging the established ones.” She added, “the same is happening between the US and China now, and also between China and Japan”, and also said that “there is potential for conflict between China and two of its other neighbours — Vietnam and Malaysia — as well.”
"We hope the mother will come to us and verify the facts. If it's true that the user is a 13-year-old who spent the money without consent, we can negotiate a refund," the Tencent employee said.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Rather than strangling the doctor (difficult, due to his injury) Jalava took the corny line as inspiration. He decided to go ahead and actually build a prosthetic finger that contains two gigabytes of digital storage. He can now jack his finger into a computer just by peeling back the nail to expose the USB plug. He can also remove the entire finger at any time and hand it to a friend to use.
As we ring in the New Year, let’s take stock of where we are at with the oil markets. 2014 proved to be a momentous one for the oil markets, having seen prices cut in half in just six months.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

近日,新一期福布斯世界富豪排行榜揭晓,比尔·盖茨在近22年内第17次问鼎榜首。
这一周发生的事情对国王来讲是火车事故:毫无说服力的否认,考辛斯在全明星周日交易的时刻,可怜的交易回报价值,
But Michael DeFranco, chair of Baker & McKenzie’s M&A practice, hailed the Chinese group’s investment in developed economies.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

As for Dirk, nobody should ever go out the way they do, but it happens all the time. In some ways, maybe it's easier if the reckoning is this painful.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 卫浴企业如何抢滩定制家居市场
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

警方在屋内查出一柄40口径的Smith & Wesson半自动手枪,目前正在进行弹道测试,检查器是否牵涉其他犯罪活动。
根据《每日经济新闻》报道,1980版的猴年生肖纪念邮票价格由于种种原因创下了历史新高。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The Asia-Pacific region was the main driver of international growth at movie houses, up 13%, and China accounted for nearly half of the entire Asia-Pacific total.
Issued by the Institute of Social Security Research, Ministry of Human Resources and Social Security, the report shows that the return rate of enterprise employees' pension insurance fund reached 3.1 percent, the highest in seven years.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

as加强+soc社会+ion→社团;联合
11月,由财新网(Caixin)赞助的中国制造业采购经理人指数(PMI)初值为48.6,高于预期的48.3。而10月份该读数则为48.3。读数显示上个月中国制造业活动在继续放缓,不过情况没有10月份那么糟糕。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

而诺贝尔物理学奖则颁给了三位生于英国、目前正在美国工作的科学家,肯定了他们对极端状态下物质的特异属性所做的原子级研究。
7.M·A·S·H Star Never Signed his Contract

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

“考虑到8月贬值行动引发负面反应,我们认为近期不会出台进一步的贬值,”常驻香港的牛津经济研究院经济学家高路易(Louis Kuijs)表示。“我们认为10月的贸易数据将继续(使政府)面临压力,要求其在国内出台更多宽松政策。”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

For: Since it premiered at the Venice Film Festival, it's being wowing audiences.
While China remains the largest holder of American government securities, it cut down exposure to USD 1.25 trillion in October.
Will China's stock market climb back to the 6,000-point mark it reached two years ago? The stock market was at its most bullish back then, but if you ask the same question now, some would cite a global economy still reeling from a recession.
两间卧室位于二楼,其中包括主卧,该卧室是一个大套间的一部分,这个套间里还有一座壁炉、一间步入式衣帽间和一座可俯瞰海湾的阳台。走廊边的一间办公室也通往这座阳台。其他的卧室都在三楼。其中有一间可通过山墙上的扇骨半圆窗俯瞰海湾。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

10月份中国非制造业商务活动指数(非制造业PMI)为54.3,低于9月份55.4的近期峰值。其中,服务业商务活动指数为53.5,比9月份的峰值回落0.9个百分点。就连建筑业的形势似乎也有所恶化,商务活动指数为58.5,较9月份回落2.6个百分点。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

China produced an estimated 420.5 tonnes of gold last year, according to the World Gold Council. Over the same period, Chinese demand for gold rose by 4 per cent to 953.3 tonnes, it said.
你可以和老师有眼神接触。不要小看这一点起到的作用。如果你的老师总是能够知道,你是很认真的在听他讲课,并且很重视学习的话,他可能会对你提供额外的帮助。除此之外,这会使你感觉,自己又多了一位私人教师。
Some smart beds will promise you better sleep and posture, but this one in particular will turn you into a private investigator looking to catch a cheating spouse in the act. Regardless of knowing if it's comfortable, the Smarttress alerts you "whenever someone is using your bed in a questionable way."

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

《暮光之城》众星前照令人大跌眼镜
而其他的队伍还有在尝试赢球的。小牛队,在3-13的战绩面前,骄傲地说他们不会垫底。但是,明年被认为是近年来最好的NBA选秀,有Markelle Fultz, Jayson Tatum, Lonzo Ball, Josh Jackson, Harry Gile, OG Anumoby, Ivan Rabb……等等优质球员。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

组建或加入一个学习小组
Bringing harmony to Apple’s internal fiefdoms has not been easy. There is still “huge tension” inside Apple, according to one person who has worked with the company for many years. “That tension is something he uses to run the company but it can be dangerous.”

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

9. 《大空头》(The Big Short)。亚当·麦凯(Adam McKay)把影片处理为喜剧,但在他以笑声轰炸屏幕的同时,也表明他对这场2008年经济崩溃的呈现是一场让人心碎的美国悲剧。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

根据研究者提供的数据,如果用户设置了真实答案,美国用户设置的"你最喜欢的食物"只需1次尝试就能成功破译的概率是19.7%;
If he wins the primary, he would face off against first-term Republican Gov. Phil Scott, 59.
周二发布的官方数据显示,中国的出口在今年10月出现了连续第二个月收缩,这表明内需是PPI上涨的主要推动因素。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 卫浴洁具行业的发展趋势与机会
Paper

Length-scale dependence of protein hydration-shell density

6、Social media addiction
Why does beauty exist? To answer this question, Richard O. Prum, an ornithologist, is working to revive an idea advanced by Charles Darwin: the attractiveness of an animal to another of its species isn’t only tied to fitness and good genes. Rather, animals — especially birds in Dr. Prum’s work — are making subjective decisions. He hopes that evolutionary biologists will stop “explaining away desire.”
里奥斯工作非常努力。她很小的时候就从萨尔瓦多来到了美国。以优异成绩从高中毕业后,她一边养家,一边读完大学。成立Nation Waste Inc.公司的时候,她并没有感到害怕。22岁的时候,里奥斯刚刚从休斯敦大学(the University of Houston)毕业几个月就贷款购买了两辆卡车,毅然投身由男性主导的垃圾处理行业。目前,这家位于休斯敦的公司有24名全职员工。里奥斯说:“回头看看过去的经历,总是让我感到吃惊。我很小的时候就跟着父母来到美国,现在我正在实现我的美国梦。”
杜邦自称“金鹰”,有着独特的,鹰隼般的外形。设计师们想塑造出那个外形,但又不想弄得跟杜邦本人一模一样。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

中公教育表示,周二报名的岗位中最抢手的是位于北京的中国就业培训技术指导中心的职位,已有1430人报考了该职位。
coach

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Moreover, a “turnaround in the short run is unlikely”, given China’s efforts to rebalance its economy from exports towards consumption (thereby reducing demand for imports of intermediate inputs), reinforced by “government policy to stimulate the use of domestic suppliers” and rising protectionism elsewhere, he argues.
其中有一支队伍我不大赞同:国王队。今年西部各队实力都有所下降,并且萨克拉门托还在季后赛席位的竞争之列,倒不是说摆烂不可能,但是只要他们还在这一队列里,他们就该全速前进,进入季后赛。
同时,该官员称,由于中央政府鼓励更多的大学毕业生到市县工作,今年的招录岗位中,有78%是区、县级的工作。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 房企又抢地 二线城市仍是主战场
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Gunmen kidnapped 18 Turkish workers Wednesday in Iraq's capital.
?奥巴马总统在纽约和新泽西宣布一场“大灾难”。洪水摧毁了海岸和超过230万人失去了电。在新泽西国家警卫队从洪水中救出数百人。州长克里斯?克里斯蒂,共和党人,说这次损失是“无法想象的”。他赞扬了从奥巴马那收到的“突出”配合。

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